Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death

Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death

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Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis.In the present study, we report that pekinenin E (PE), a casbane diterpenoid derived from the roots of Euphorbia pekinensis, has a strong antitumor activity against Hockey Accessories - Tape human HCC cells both in vitro and in vivo.PE suppressed the growth of human HCC cells Hep G2 and SMMC-7721.In addition, PE-mediated endoplasmic reticulum (ER) stress caused increasing expressions of C/EBP homologous protein (CHOP), leading to apoptosis in HCC cells both in vitro and in vivo.Inhibition of Dryer Air Inlet Grille ER stress with CHOP small interfering RNA or 4-phenyl-butyric acid partially reversed PE-induced cell death.

Furthermore, PE induced S cell cycle arrest, which could also be partially reversed by CHOP knockdown.In all, these findings suggest that PE causes ER stress-associated cell death and cell cycle arrest, and it may serve as a potent agent for curing human HCC.